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Early signs that distinguish autism from other atypical patterns of development include poor use of eye gaze, lack of gestures to direct other people's attention (especially to show things of interest), decreased social responsiveness, and lack of age-appropriate play with toys (especially imaginative use of toys).

A typical symptom of autism is absence of speech development, observed from infancy, taking the form of complete mutism at later stages.

Psychological testing is recommended in the AACAP practice parameter to assess for cognitive and intellectual functioning, in order to determine eligibility and plan for educational and other services.Early diagnosis and early intensive treatment have the potential to affect outcome, particularly with respect to behavior, functional skills and communication.There is increasing evidence that intervention is more effective when initiated as early as possible.It has been emphasized that most pathological symptoms of autism result from altered perception of external stimuli, which arouse fear and anxiety.Currently, there are no biological markers for autism and there is no proven cure for this disorder.: Neuropsychological or psychological testing (see CPB 0158 - Neuropsychological and Psychological Testing) beyond standardized parent interviews and direct, structured behavioral observation is rarely considered medically necessary for the diagnosis of pervasive developmental disorders.

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